CORDIS Project
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This project aims to identify microbial triggers of inflammatory bowel diseases by analyzing the immune response to gut microbiota. It employs a novel sequencing method to pinpoint microbes targeted by the immune system in patients with Crohn's disease and ulcerative colitis.
The inflammatory bowel diseases (IBD) Crohn’s disease and ulcerative colitis manifest at the host-microbiota interface.
The recently revealed genetic underpinning of IBD points towards an aberrant immune response to the intestinal microbiota.
The prediction of genetically-impaired microbial handling is exemplified by key risk genes overlapping between leprosy, an infectious disease, and Crohn’s disease. A vigorous search for microbial triggers of IBD, which could also help explain the rising inc…
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