CORDIS Project
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This project investigates how the immune system interacts with gut microbiota in mammals, focusing on children with early-onset colitis and the role of specific bacteria in immune system development. It combines human studies and mouse models to enhance understanding of gut health and inflammatory bowel disease.
How the immune system controls the partnership established between mammalian hosts and the complex microbial community that colonizes their distal intestine is a fascinating topic with wide implications in physiology and pathology.
In order to delineate how the two partners build and maintain mutualistic relationships, we intend to combine bench to bed-site approaches in humans and mechanistic studies in mice.The first part of the proposal aims at dissecting human host pathways mandatory to main…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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