CORDIS Project
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This project aims to understand how metabolic changes in the tumor microenvironment affect anti-cancer immunity. By analyzing metabolic pathways, it seeks to identify targets for enhancing T cell function and breaking immunosuppression in cancer therapy.
Anti-cancer immunotherapy has provided patients with a promising treatment.
Yet, it has also unveiled that the immunosuppressive tumor microenvironment (TME) hampers the efficiency of this therapeutic option and limits its success.
The concept that metabolism is able to shape the immune response has gained general acceptance.
Nonetheless, little is known on how the metabolic crosstalk between different tumor compartments contributes to the harsh TME and ultimately impairs T cell fitness within t…
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