CORDIS Project
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This project investigates the immune response of the gastrointestinal tract following a stroke, focusing on how changes in gut permeability may influence recovery and infection risk. The research aims to identify potential therapeutic approaches to improve outcomes for stroke patients, particularly in the elderly.
Stroke is a multiphasic process, with an initial ischemic phase followed by secondary progression of injury from inflammatory responses which affects and being affected by remote organs and systems outside of the central nervous system.
The gastrointestinal tract constantly communicates with the brain in a complex network of interactions generally termed the ‘gut-brain axis’.
Following brain ischemia, the intestinal epithelial barrier becomes permeable, exposing gut immune cells to extrinsic mol…
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