CORDIS Project
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The project focuses on understanding how regulatory T cells (Tregs) develop in different lymph nodes, particularly in the gut. It aims to identify molecules secreted by specific stromal cells that influence Treg differentiation, which could lead to advancements in treating autoimmune diseases.
Regulatory T cells (Tregs) are essential for maintenance of immune homeostasis and peripheral tolerance.
The unique challenge to discriminate between pathogens and commensals requires the dynamic adaptation of Tregs to the microenvironment, particularly in the intestinal mucosa.
Accordingly, although Tregs are primarily generated in the thymus, they can be also generated in the periphery, and gut-draining mesenteric lymph nodes (mLN) were shown to display a higher Treg-inducing capacity compared…
HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
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