CORDIS Project
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This project investigates the distinct roles of different phosphoinositide 3-kinase genes in biological functions and diseases. Using a mass spectrometry-based approach, it aims to quantify how these genes affect protein kinases, potentially leading to biomarkers for drug development targeting specific PI3K isoforms.
The group of genes termed phosphoinositide 3-kinase (PI3K for short) have roles in many important biological functions and are also implicated in diseases such as diabetes, inflammation, allergy and cancer.
Therefore, there are many pharmaceutical and biotechnological companies interested in targeting this pathway.
There are 8 different PI3K genes and it is becoming clear that they have different functions and are involved in different diseases.
However, although the distinct biological roles of…
QUEEN MARY UNIVERSITY OF LONDON
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