CORDIS Project
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This project focuses on improving the diagnosis and treatment of magnesium-wasting kidney disorders by developing urine-based diagnostic tools and patient-specific kidney models. It aims to enhance understanding of kidney function and test new therapies using advanced imaging techniques and stem cell-derived organoids.
BACKGROUND | Renal tubulopathies are a large group of genetic disorders that disturb the function of the kidney tubule. A major challenge for diagnostics and treatment of magnesium (Mg2+) wasting tubulopathies, is absence of functional cell models and tools to study the pathophysiology.
Diagnostics of hereditary Mg2+ wasting tubulopathies based on genetic screening, rather than biological measurements of kidney processes.
Therapy largely depends on oral supplements because therapeutics that targ…
STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
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