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The INCAGE project investigates how septins, components of the cytoskeleton, interact with the bacterium Shigella flexneri to form cage-like structures that target the bacteria for degradation. This research aims to understand the assembly of these structures and their role in bacterial persistence and immunity.
Autophagy, an intracellular degradation process, is an important defence mechanism against pathogenic bacteria, including the Gram-negative enteroinvasive human pathogen Shigella flexneri.
Work has shown that septins, a component of the cytoskeleton that interacts with membranes, entrap cytosolic Shigella in cage-like structures for targeting to autophagy.
However, the factors mediating septin cage formation are mostly unknown.
The Mostowy lab has recently discovered that mitochondria are requir…
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
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IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom, LONDON
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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