CORDIS Project
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The INCANTAR project focuses on the role of transcription factors TFEB and TFE3 in cancer development, particularly in inherited syndromes. By identifying novel regulators and exploring therapeutic strategies, it aims to provide insights into the mechanisms of tumorigenesis and potential treatments.
Transcription factors EB and E3 (TFEB and TFE3), members of the MiT-TFE family, are master controllers of lysosomal biogenesis and autophagy.
The activity of TFEB and TFE3 is regulated by mechanistic Target Of Rapamycin Complex 1 (mTORC1), a central hub of cell metabolism, which inhibits their cytoplasm-to-nucleus translocation.
We recently discovered that mTORC1 phosphorylates TFEB and TFE3 via a non-canonical TORC1 (NC-mTORC1) signaling mechanism, providing the first evidence that mTORC1 can p…
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NEXT GENERATION DIAGNOSTIC SRL
Italy, Pozzuoli
Type: SME
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: Yes
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