CORDIS Project
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This project aims to develop innovative tools to study the role of Peptidyl Arginine Deiminase in rheumatoid arthritis. The research will focus on identifying modulators and inhibitors that could lead to new therapeutic strategies for this autoimmune disease.
Roughly 1% of the world’s population is affected by rheumatoid arthritis (RA); a devastating autoimmune disease causing cartilage destruction and bone erosion.
Recent evidences suggest that dysregulation of Peptidyl Arginine Deiminase (PAD) levels are associated with the onset of the disease, leading to the production of antibodies targeting the citrullinated neoepitopes.
The exact role of each of the PAD isotypes in these pathological processes is unknown and fundamental questions on the intrac…
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