CORDIS Project
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This project investigates the mechanisms by which pathogens evade human defenses by residing in pathogen-containing vacuoles. It aims to develop strategies to destabilize these vacuoles, focusing on the bacterium Chlamydia trachomatis to improve treatment options for infections.
Many clinically important pathogens invade human cells and evade their intrinsic defenses by hiding within pathogen-containing vacuoles (PCVs).
Hence, it may be feasible to combat such microbes by deliberately destabilizing their PCVs.
To promote progress towards such an innovative therapeutic concept, I propose a 5-year research program in which my team will generate a molecular mechanistic understanding of how the PCV is maintained, how it can be destabilized, and how the consequences of PCV d…
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