CORDIS Project
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This project investigates the assembly of bacterial pili, which are crucial for pathogenicity, to develop new peptide inhibitors that could combat antibiotic resistance. It focuses on understanding the chaperone-usher pathway in Escherichia coli to inform the design of these inhibitors.
Currently, the control of infectious diseases caused by pathogenic organelles displayed on bacteria is challenging for alternatives to antibiotic treatments.
In this regard, the OMS report of 2010 alerted of the raising of antibiotic resistance for the control of human infections.
Many of these pathogenic organelles, also known as pili or fimbriae, are assembled by a specific secretory machinery called the chaperone-usher pathway (CU).
The aim of this proposal is the study of the initial steps r…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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