CORDIS Project
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This project investigates the role of the NLRP6 inflammasome in regulating the gut microbiota and its impact on intestinal inflammation. By using genetically modified mouse models, it aims to understand how changes in microbiota composition affect immune responses and disease severity.
Inflammasomes are multi-protein complexes that control the activity of the cysteine protease caspase-1.
Inflammasomes are assembled around one of several different sensor proteins, which enable inflammasome activation after sensing of diverse microbial and endogenous damage-associated molecules.
Recently, I discovered a novel role for the NLRP6 inflammasome in regulation of the intestinal microbiota of mice.
In its absence an altered microbiota, called dysbiosis, develops that increases the seve…
HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
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