CORDIS Project
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This project focuses on developing novel inhibitors targeting the NOTCH signaling pathway in cancer cells to improve treatment outcomes. By specifically activating these inhibitors in hypoxic tumor regions, the aim is to enhance the effectiveness of cancer therapies while minimizing side effects on healthy tissues.
Cancer remains one of the deadliest diseases and most deaths are due to treatment failure and metastasis.
Tumor resistance and patient outcome are strongly associated with tumor heterogeneity, which is promoted by the self-renewing and multipotent cancer stem cells (CSC) and by limitations in oxygen availability generating hypoxic areas within the tumor microenvironment.
The NOTCH signaling pathway is one CSC pathways frequently deregulated in human cancers but also essential in many normal tiss…
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