CORDIS Project
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This project explores the role of Group 2 innate lymphoid cells in mucosal defense and tissue homeostasis, focusing on how they respond to environmental signals through neuromedin U signaling. It aims to uncover the molecular mechanisms that regulate ILC2 function.
Group 2 innate lymphoid cells (ILC2) are critical players in mucosal defense, tissue homeostasis and inflammation. ILC2 development and function have been widely perceived to be programmed.
Nevertheless, how ILC2 perceive, integrate and respond to environmental cues remains mostly unexplored.
Here we hypothesize that ILC2 sense their environment and exert their function as part of a novel neuronal-ILC2 unit orchestrated by neuromedin U (NmU) signaling.We propose to employ genetic, cellular and m…
FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD
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