CORDIS Project
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This project investigates how changes in DNA methylation can serve as biomarkers to predict responses to anti-angiogenic therapies in metastatic colorectal cancer. By analyzing circulating free DNA, it aims to develop a test that can provide early indications of treatment effectiveness.
Tumors are characterized by a disorganized vasculature, leading to profound levels of hypoxia.
Normalizing the blood vessel formation (angiogenesis) in tumors has therefore become an attractive therapeutic strategy, leading to the development of approved drugs that inhibit major angiogenic pathways.
Resistance however restricts the success of these anti-angiogenic drugs in some patients.
There is thus a great clinical need for readily accessible markers that serve as reliably predictive biomarke…
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