CORDIS Project
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This project aims to identify new proteins that sense cytoplasmic DNA and trigger the immune response, specifically the production of type I interferons. By exploring these proteins, the research could enhance understanding of immune responses to infections and inform therapeutic strategies for autoimmune diseases and…
Detection of pathogens by the innate immune system depends on the recognition of microbial components by dedicated receptors.
During viral and bacterial infections, pathogen-derived nucleic acids are recognized by innate receptors resulting in the production of type I IFNs and inflammatory cytokines.
While it is established that cytoplasmic delivery of viral, bacterial and even host DNA triggers type I IFN production via a pathway depending on STING, TBK1, IKKe and IRF3, the identification of th…
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