CORDIS Project
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This project investigates the role of liver innervation in the development of bile ducts. By analyzing nerve connections and their influence on biliary tubulogenesis, the research aims to uncover fundamental mechanisms that could inform future therapeutic strategies for liver diseases.
While liver development is well-studied, the signal initiating tubulogenesis of bile ducts therein remains to be identified.
Neurites are present in the liver before bile duct tubulogenesis, and in other organs, innervation can instruct tubulogenesis.
However, a role for liver innervation in biliary tubulogenesis has not been shown.
Preliminary data from my host lab suggest a strong link between both processes:
Defective biliary tubulogenesis caused by Notch mutations in Alagille syndrome (ALGS)…
KAROLINSKA INSTITUTET
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