CORDIS Project
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This research examines the Caf1 antigen of Yersinia pestis to understand its immune evasion mechanisms. By altering the antigen's structure, the project aims to enhance its recognition by the immune system, paving the way for improved vaccine development against plague.
The structure and thermodynamic properties of Y. pestis capsular Caf1 antigen were studied to explain the failure of this protein to induce the cellular immune response.
During the assembling of the Caf1 capsule, the collapse of Caf1 hydrophobic core results in the formation of extremely stable Caf1 fibers.
This increases resistance of the Caf1 antigen to processing in macrophages and thereby abolishes the cellular immune response.
Destabilization of Caf1 by heating caused a shift toward present…
TURUN YLIOPISTO
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