CORDIS Project
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This project investigates how cells manage phosphate levels, a critical resource for growth and metabolism. It aims to identify new pathways for phosphate signaling and storage, using yeast as a model to understand cellular homeostasis and its implications for metabolism.
Cells face a phosphate challenge.
Growth requires a minimal concentration of this limiting resource because intracellular phosphate (Pi) is a compound of nucleic acids and modifies most cellular proteins.
At the same time, cytosolic Pi may not rise much, because elevated cytosolic Pi can stall metabolism.
It reduces the free energy that nucleotide triphosphate hydrolysis can provide to drive energetically unfavorable reactions. I will undertake a pioneering study to elucidate how cells strike th…
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