CORDIS Project
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This project investigates how molecular chaperones assist in protein folding and maintenance within living cells. By using advanced imaging and biochemical techniques, it aims to understand the dynamics of chaperone systems and their role in maintaining protein stability, particularly under stress conditions associated…
Molecular chaperones mediate protein folding and conformational maintenance.
Failure of these fundamental cellular functions results in a breakdown of protein homeostasis (proteostasis) and facilitates the manifestation of diseases associated with protein aggregation.
Much progress has been made in understanding the mechanisms of individual chaperone systems, such as the Hsp70s and the chaperonins, based on analyses in vitro.
How these machineries function in the intact cell is not well understo…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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