CORDIS Project
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This project explores the molecular mechanisms that regulate gene expression during vertebrate limb development. It focuses on how various signaling pathways interact to control gene regulatory landscapes, with implications for understanding organogenesis and related diseases.
Identification of the molecular mechanisms by which gene regulatory landscapes integrate diverse signaling inputs into a robust and dynamic transcriptional output is key to a comprehensive mechanistic understanding of the systems that govern vertebrate organogenesis.
We will tackle this by taking advantage of our in-depth knowledge of the self-regulatory signaling systems controlling vertebrate limb development.
To capture the dynamics by which the major signaling pathways (BMP, SHH, WNT, FGF) i…
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