CORDIS Project
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This project aims to develop personalized gene therapies for treating lower back pain by targeting the unique microenvironment of degenerated intervertebral discs. By profiling individual patient conditions, the project seeks to enhance regeneration and reduce inflammation through tailored biomaterials and cell therapi…
Lower back pain is a global epidemiological and socioeconomic problem.
Biomaterial and cell-based therapies have been pursued for the treatment of degenerated intervertebral disc (IVD), with a number of clinical trials underway.
However, the degenerated intervertebral disc has a distinct environment (e.g. altered oxygen, glucose, acidity, inflammatory cytokine levels) that is unique to an individual (i.e. patient-specific) and will ultimately determine the likelihood and rate at which regenerati…
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