CORDIS Project
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This project investigates how cellular systems adapt to genetic and environmental changes, focusing on the robustness of metabolic networks. By combining functional genomics with evolutionary experiments, it aims to understand how genetic perturbations affect cellular growth and how compensatory mutations evolve.
The ability of cellular systems to adapt to genetic and environmental perturbations is a fundamental but poorly understood process both at the molecular and evolutionary level.
There are both physiological and evolutionary reasonings why mutations often have limited impact on cellular growth.
First, perturbations that hit one target often have no effect on the overall performance of a complex system (such as metabolic networks), as perturbations can be adjusted by reorganizing fluxes in metaboli…
HUN-REN BIOLOGICAL RESEARCH CENTRE SZEGED
HUN-REN SZEGEDI BIOLOGIAI KUTATOKOZPONT
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