CORDIS Project
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This project explores the interactions between mammary epithelial cells and their environment, focusing on stem cell behavior in normal development and cancer. It investigates the role of specific receptors in regulating cell functions during these processes.
Understanding the functional interactions between mammary epithelium and its microenvironment, with a particular focus on the stem cell niche, represents a challenge for developmental and cancer biologists.
Mammary epithelium is a bilayer, with a layer of luminal cells, producing milk, and a layer of basal myoepithelial cells.
Both layers contain clonogenic stem/progenitor cells, which ensure the drastic epithelial expansion in puberty and pregnancy.
Whilst basal stem cells are thought to be bip…
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