CORDIS Project
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This project investigates the mechanisms of cell polarity in the intestinal epithelium of Drosophila, aiming to identify novel regulators through genetic screening. It seeks to understand how these pathways differ from established polarity mechanisms in other cell types, contributing to our knowledge of epithelial biol…
Cell polarity is essential for normal cell function and for various developmental processes, such as axis determination, asymmetric stem cell divisions, and cell migration.
Polarity is integral for tissue organization and failure in this process is a hallmark of human malignancies.Extensive studies in diverse model systems have helped to establish recurring mechanisms that drive polarity in various cell types.
Yet, these conserved polarity regulators are not universally required and it emerges t…
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