CORDIS Project
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This project aims to explore the mechanics of viral infection by studying how viral capsids bind to host cell membranes. Using advanced microscopy techniques, it seeks to understand the forces and structural properties involved in this process.
Viruses are nano-sized, genome-filled protein containers with metastable mechanical properties.
They form by spontaneous self-assembly inside the crowded, heterogeneous environment of the infected cells.
While structural characterization of viruses is becoming increasingly more refined, essential questions about the viral life cycle remain unanswered up to date.
This includes: (i) how do the capsomeres (capsid proteins) rearrange during the infection cycle of a viral capsid? (ii) What are the in…
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