CORDIS Project
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This project investigates the motility of malaria-causing parasites, focusing on a newly identified protein called LIMP. It aims to understand how LIMP contributes to the parasite's movement and invasion of host cells, which is crucial for developing new malaria treatments.
Sporozoites are the motile forms of the malaria causing parasite Plasmodium and are injected into the vertebrate host by a mosquito.
Their motility is powered by the parasites own actin-myosin motor, which is connected to transmembrane proteins of the TRAP (thrombospondin-related anonymous protein) family which serve as force transmitters.
This substrate-dependent locomotion is a prerequisite for tissue penetration and host cell invasion.
The glycolytic enzyme aldolase was thought to be the link…
UNIVERSITATSKLINIKUM HEIDELBERG
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