CORDIS Project
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This project focuses on understanding the internalization mechanisms of the glucagon-like peptide-1 receptor, a key target for type 2 diabetes treatment. It aims to develop genetic tools to study the pathways involved in receptor signaling and internalization.
Glucagon-like peptide-1 is a key regulator of insulin and blood glucose release.
The cognate receptor, the glucagon-like peptide-1 receptor (GLP-1R), a class B GPCR is a major drug target for type 2 diabetes.
Agonist-induced internalization is a major regulatory mechanism for GPCR signalling.
Interestingly, GLP-1R internalizes via a mechanism that is distinct from the canonical beta-arrestin mediated pathway.
However, the details of the exact mechanism is largely conflicting and poorly understoo…
KOBENHAVNS UNIVERSITET
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