CORDIS Project
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This project investigates the metabolic interactions between cancer and stromal cells to identify how they utilize nucleotides from various sources. By employing advanced single-cell techniques, it aims to uncover vulnerabilities in cancer cells that could lead to more effective and personalized anticancer therapies.
Anticancer therapy is >70 years old, and nucleotides are the oldest target in cancer treatment.
Despite its long history, this treatment suffers high rates of resistance and toxicity.
What are the reasons? A cell can gain nucleotides via de novo synthesis (DNS) or from salvage pathways. DNS inhibition can be bypassed by nucleotides produced by surrounding cells or distant organs, causing resistance.
Cancer cells were traditionally studied in isolation, with (bulk) techniques precluding identific…
IBT INSTITUTE OF BIOTECHNOLOGY AS CRVVI
BIOTECHNOLOGICKY USTAV AV CR VVI
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