CORDIS Project
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This project develops a new method called inteRNAlizers for delivering RNA into human induced pluripotent stem cells and other hard-to-transfect cells. It aims to improve gene expression and editing capabilities while ensuring safety and cost-effectiveness for biomedical research and therapeutic applications.
Human induced pluripotent stem cells (hIPSCs) have revolutionized the study of cell type-specific processes and the generation of organoids, tissues, and therapeutic cells for biomedical purposes.
However, the genetic modification of these cells, along with other difficult-to-transfect cells, poses a major challenge for performing high-throughput gene reporter and genetic perturbation assays and prevents us from fully exploiting the potential of hIPSCs.Existing gene delivery techniques, such as…
TECHNISCHE UNIVERSITAET MUENCHEN
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