CORDIS Project
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This research focuses on the SHH morphogenetic pathway, exploring its role in cell behavior and tumor formation. It aims to track the dynamics of GLI3 proteins to understand how cells respond to SHH signals during development.
The SHH morphogenetic pathway exerts multiple functions during embryonic and adult life.
It is involved in various cellular contexts to provide positional information, but also controls cell survival, proliferation and differentiation.
Aberrant activation of the pathway has also been linked to tumour formation and growth.
The SHH signal is integrated by receiving cells via the GLI transcription factors, which regulate the expression of SHH target genes.
In particular, the GLI3 protein is process…
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