CORDIS Project
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This project focuses on the TASK-3 potassium channel, exploring its role in neurological diseases and cancer. It aims to develop antibodies to inhibit TASK-3 function and investigate its molecular interactions to enhance understanding of its structure and trafficking, ultimately guiding therapeutic strategies for ion c…
TASK-3 is a potassium channel member of the recently discovered two-pore potassium channels family (K2P) responsible for the background current maintaining the membrane resting potential. TASK-3 is involved in several neurological diseases but recent studies pointed out its oncogenic potential. TASK-3 aberrant expression was detected in breast, lung and colorectal cancer cells.
This research proposal aims at 1) generate antibodies that can directly reduce TASK-3 function.
The potency, the bindin…
UNIVERSITA DEGLI STUDI DI PAVIA
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