CORDIS Project
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This project examines the role of dendritic cells in inflammatory bowel diseases (IBD) and their influence on T-cell responses. It aims to identify how changes in dendritic cell populations affect T-cell homing and function, potentially leading to improved therapies for IBD.
Inflamatory bowel diseases (IBD) are systemic diseases characterized by intestinal inflamation and extra-intestinal manifestations.
The compartimentalisation of inflammatory processes is driven by immunological mechanisms, in particular pertaining to homing and trafficking of immune cells.
Intestinal Dendritic Cells (DC) are professional antigen presenting cells that recognize antigens and direct subsequent immune response. DC also dictate the type of T-cell immune response (e.g. pro-inflamatory…
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