CORDIS Project
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This project focuses on improving cancer immunotherapy for children with B-cell acute lymphoblastic leukemia, particularly those with mixed-lineage leukemia rearrangements. It aims to develop a bispecific chimeric antigen receptor T cell therapy to enhance treatment efficacy and address challenges related to tumor anti…
B-cell acute lymphoblastic leukemia (B-ALL) is the commonest cancer in children and B-ALL with mixed-lineage leukemia rearrangements (MLLr) has a particularly dismal prognosis compared with other B-ALLs.
Many MLLrB-ALL patients are refractory to chemotherapy and eventually relapse.
Thus, MLLrB-ALL remains clinically challenging.
Adoptive transfer of T cells engineered to express artificial chimeric antigen (Ag) receptors (CARs) targeting tumor cell surface-specific Ag is an exciting new approach…
INSTITUT JOSEP CARRERAS - CERCA
FUNDACIO INSTITUT DE RECERCA CONTRA LA LEUCEMIA JOSEP CARRERAS
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