CORDIS Project
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This project aims to investigate the role of microglia in the early stages of Alzheimer's disease, focusing on the accumulation of amyloids in specific neurons. It seeks to develop neuroprotective therapies by understanding the interplay between microglia and neuronal death.
The recently approved drugs for Alzheimers disease (AD), targeting amyloid plaques removal, only mildly slow patients cognitive decline as neuronal loss starts decades before plaque deposition.
To delay AD onset before symptoms development, prevention of neuronal death should be prioritised instead.
An early AD pathological event is intraneuronal accumulation of amyloids (intraA) which can cause neuronal death at the pre-plaque stage.
IntraA is only found in specific neuronal subtypes first to b…
UNIVERSITA DEGLI STUDI DI TORINO
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