CORDIS Project
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This project investigates how intrinsic receptors within macromolecular complexes help maintain cellular quality control by regulating the degradation of dysfunctional complexes through selective autophagy. It aims to uncover the mechanisms of these receptors and their role in age-related diseases.
Macromolecular complexes (MC) are cellular machines that perform a wide array of vital tasks.
They operate in a controlled, coordinated fashion within the crowded environment of the cell.
Accumulation of dysfunctional MCs leads to age-related diseases.
Despite recent technological advancements, it still remains elusive for many of them how excess or dysfunctional MCs are sensed and removed. I have recently established a role of intrinsic receptors in degradation of the nuclear pore complex and t…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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