CORDIS Project
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This project explores the role of transposable elements in human placental function and their potential link to pregnancy complications. By mapping these genetic sequences and using advanced genome editing techniques, it aims to uncover the regulatory mechanisms that could contribute to better understanding and treatme…
Aberrant epigenetic regulation of placental function is implicated in several complications of pregnancy, such as preeclampsia, recurrent pregnancy loss and fetal growth restriction.
Notably, the placenta has a unique epigenetic landscape, permissive for the activity of transposable element (TE) derived DNA sequences. TEs are often co-opted by the host genome as cis-regulatory elements, driving tissue- and species-specific gene expression programs.
Indeed, TEs contribute many placental-specific…
QUEEN MARY UNIVERSITY OF LONDON
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