CORDIS Project
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This project investigates DNA replication in eukaryotic cells using advanced single molecule techniques. By observing individual DNA replication processes, the project aims to understand the dynamics and mechanisms involved, which could enhance our knowledge of cellular functions and inform future disease treatments.
For cells to reproduce, an accurate duplicate of the genome must be created.
This is no small task.
The genetic information stored in each cell consists of ~6 billion pairs of nucleobases (base pairs, bp) assembled as a polymer 2 metres long and 2 nanometres in diameter, with the structural form of a double helix.
For a mammalian cell to divide, this deoxyribonucleic acid (DNA) must be copied in a time frame on the order of 1 day, or ~70,000bp a second. DNA replication is common to all 3 domains…
THE FRANCIS CRICK INSTITUTE LIMITED
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