CORDIS Project
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This project investigates the mechanisms behind histone demethylases, enzymes that regulate gene expression by modifying histones. It aims to understand how these enzymes selectively demethylate specific histone residues, contributing to our knowledge of chromatin regulation and epigenetics.
Histone modifications play important roles in chromatin regulation.
Methylation of lysine-residues on histone H3 and H4 affects processes ranging from transcriptional regulation to epigenetic silencing.
The recent identification of histone lysine demethylases has clearly demonstrated that histone methylation is not a stable epigenetic mark, as previously assumed.
The largest family of demethylases employ 2-oxoglutarate as a co-substrate.
Each of these demethylases displays remarkable sequence an…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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