CORDIS Project
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This project investigates the role of the Trib2 gene in Acute Myeloid Leukemia (AML). By examining its mechanisms and interactions, the research aims to uncover new insights into the disease's pathogenesis and identify potential therapeutic targets.
Acute Myeloid Leukemia (AML) is a poorly treatable leukemia in which a limited set of genes are involved.
Trib2 is a gene that has not previously been associated with leukemia.
My goal is to understand the pathogenesis of Trib2-induced acute myelogenous leukemia (AML). I identified Trib2 as a novel leukomogen that efficiently induces a clonal, transplantable AML in mice.
Trib2 inhibits C/EBPalpha to cause AML, and elevated Trib2 expression associates with a cluster of human AML samples that have…
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
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