CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project focuses on understanding the dependency of cancer cells with RAS mutations on matrix metalloproteinase-7 for survival. It aims to explore the underlying mechanisms and identify potential therapeutic targets for treating RAS-driven tumors.
Activating point mutations in RAS are present in a large number of tumours.
Besides treating tumours by reversing the effects of oncoproteins through inhibition, another approach is to use therapies that target tumour-specific vulnerabilities caused by the oncogenic state.
To investigate this possibility, an siRNA screen has been performed in order to identify new genes necessary for the RAS-driven oncogenic state.
This approach has led to the identification of the matrix metalloproteinase-7 (MM…
CANCER RESEARCH UK LBG
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
