CORDIS Project
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This project investigates the role of ADP-ribosylation in the DNA damage response using the model organism Caenorhabditis elegans. By employing advanced proteomic techniques, it aims to map ADP-ribosylated peptides and understand their biological impact on DNA repair mechanisms, potentially informing treatments for DNA…
Preservation of genome integrity and stability is critical for survival and propagation of individuals and species.
Organisms have thus evolved rapid and efficient mechanisms -collectively termed the DNA damage response (DDR)- to combat threats posed by DNA damage.
Among these, the post-translational modification (PTM) ADP-ribosylation (ADPR) plays a decisive role in effective DDR.
Although much is known about the relevance of ADPR upon DNA injury, the underlying molecular mechanisms are still p…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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