CORDIS Project
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This project aims to explore the mechanisms of action of nuclear receptors involved in cell differentiation and growth using retinoic acid as a model. It combines in vitro and in vivo studies to uncover gene expressions and pathways related to these processes.
Cell proliferation, differentiation and death are controlled by different transcription factors amongst which the non-steroid nuclear receptors (nsNR).
Deciphering the mechanisms of action of nsNR is a challenge in various research fields ranging from cancer and neurodegenerative disorders to metabolic diseases.
According to the canonical signalling pathway liganded nsNR, in the form of dimers with a rexinoid receptor (RXR), bind to specific DNA response element of target genes and activate tran…
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
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