CORDIS Project
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This research focuses on the role of iRhoms in regulating the release of TNFalpha, a key inflammatory cytokine. By understanding the interaction between iRhom2 and ADAM17, the project aims to develop inhibitors that could manipulate inflammation in diseases like cancer.
The primary inflammatory cytokine, TNFalpha, is a transmembrane protein that requires cleavage by the metalloprotease ADAM17 for its release.
Aberrant release of TNFalpha is a hallmark of cancer, chronic inflammation and autoimmune syndromes.
The rising prevalence of these widespread diseases necessitates new approaches to manipulate inflammatory signalling, which is the overarching goal of this proposal.
Recent studies demonstrate that iRhoms regulate trafficking, maturation and stability of AD…
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