CORDIS Project
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This project investigates the metabolic mechanisms linking type 2 diabetes to liver cancer, focusing on specific enzymes that may regulate tumor growth. The goal is to identify potential therapeutic targets to improve treatment outcomes for patients with diabetes-related liver cancer.
Hepatocellular carcinoma (HCC), the most common primary liver cancer, has survival rates below 20%.
Type 2 diabetes (T2D) markedly increases HCC incidence by driving metabolic and inflammatory changes, but the underlying mechanisms are unclear.
Emerging evidence points to altered glutamine metabolism via the glutaminase isoenzymes GLS and GLS2 as a key link, though its role in diabetes-driven HCC remains unexplored.This project aims to elucidate how GLS and GLS2 regulate tumor bioenergetics, met…
FUNDACION PARA LA INVESTIGACION DE MALAGA EN BIOMEDICINA Y SALUD
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