CORDIS Project
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This project investigates the assembly of nuclear pore complexes, which are essential for molecular transport between the nucleus and cytoplasm. By analyzing assembly intermediates in genetically modified yeast, it aims to enhance understanding of the mechanisms involved, with implications for cancer and degenerative d…
Nuclear pore complexes (NPCs) are fundamental supra-molecular complexes mediating the molecular traffic between nucleus and cytoplasm.
They consist of over 1000 proteins that need to be assembled in a coordinated manner each cell division.
Recent structural work has elucidated a considerable part of the NPC architecture, however how the NPC scaffold is assembled remains poorly understood on the structural and mechanistic level.
Here I propose for the first time to arrest and structurally analyze…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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