CORDIS Project
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This project explores how prenatal stress affects male and female brain development, focusing on the role of microglia, the brain's immune cells. It aims to uncover the mechanisms behind sex-specific vulnerabilities to neurodevelopmental disorders.
Prenatal stress (PS) is more detrimental to males than to females.
Evidence is accumulating that PS may play an important etiological role in the incidence of neurodevelopmental disorders, which often show a male bias in incidence.
The mechanisms underlying the sex-specific effects of PS are still unknown, but recent evidence implicates a crucial role for microglia, the resident immune cells of the central nervous system.
Although in the adult brain microglia are activated only after infection o…
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
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