CORDIS Project
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This project aims to understand the assembly process of human mitochondrial ribosomes, which are essential for synthesizing proteins involved in energy production. By using advanced imaging techniques, the research seeks to identify the factors and mechanisms that regulate ribosome maturation in mitochondria.
Human mitoribosome represents a distinct class of ribosomes that has specialized in synthesizing exclusively 13 hydrophobic membrane proteins, forming the catalytic core of the respiratory chain.
The mature mitoribosome is composed of 82 nuclear encoded proteins and three mt-rRNAs.
It is postulated that mitoribosomes are formed in an intricate and well-defined hierarchical process, involving hundreds of proteins and RNA molecules working in cooperation and under tight regulation.
However, a stru…
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