CORDIS Project
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This project aims to explore the interaction between RAS and RAF proteins in lung adenocarcinoma, focusing on developing new therapeutic strategies to inhibit this interaction. By utilizing a novel mouse model, the research seeks to understand how disrupting this interaction affects tumor growth and the surrounding tis…
Lung adenocarcinoma is the most frequent subtype of lung cancer and patients harbour activating mutations in the KRAS gene in approximately 25% of the cases.
Unfortunately, regardless of the outcome of recent studies identifying specific KRASG12C inhibitors, so far, oncogenic KRAS is not a druggable target yet.
The best-characterized KRAS effector pathway, the ERK cascade consists of RAF, MEK and ERK proteins that can be inhibited with small molecules targeting their kinase activities.
As the de…
THE FRANCIS CRICK INSTITUTE LIMITED
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